In 1849, the German pathologist Friedrich Theodor von Frerichs, brought medical recognition of MS a step closer by elaborating on the clinical description of MS provided by Cruveilhier and identifying specific symptoms and key features of the illness.
Frerichs’ clinical account for the first time recognised remissions as a characteristic feature of MS. In addition, he described nystagmus (jerky eye movements) as a symptom of the disease, this sign later being incorporated into the famous Charcot’s triad.
Frerichs also made a major contribution by providing the first medical description of mental disorders in MS, recognising the possible impact of the disease on cognitive and other higher functions of the brain.
“It is remarkable how accurately our predecessors were when describing what we know in the modern era as MS.”
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